- Her father was a U.S. Army colonel employed at the Pentagon.
- Her mother worked as a banker.
- Her family history was researched for an episode of the 2012 PBS genealogy program, Finding Your Roots with Henry Louis Gates Jr.
- Her ancestry was traced back to a 1683 court case involving her ancestor, Elizabeth Banks, a free white woman and indentured servant, who gave birth to a biracial child, Mary Banks, fathered by a slave, who inherited her mother's free status.
- She was a member of Alpha Kappa Alpha.
- She performed in front of a live audition in 1987.
- She served as a correspondent for HBO's Inside the NFL.
- Sykes co-hosted the 94th Academy Awards with Regina Hall and Amy Schumer.
- She performed as part of Cyndi Lauper's True Colors Tour for LGBT rights in 2008.
- Entertainment Weekly named her one of the 25 funniest people in America in 2004.
- She appeared in a television ad for the Think Before You Speak Campaign, an advertising campaign by GLSEN in October 2008 aimed at curbing homophobic slang in youth communities.
- She is an outspoken supporter of same-sex marriage.
Wanda Sykes Trivia
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